After losing three weeks with left shoulder discomfort, left-hander Hector Santiago will rejoin the rotation and will be the Twins’ starter on Tuesday (7:10 pm ET) in the second game of the series of four against the Red Sox At Fenway Park. Lefty left-hander Drew Pomeranz (6-4, 4.07 ERA) will take the ball over Boston.

It is the first opening of Santiago (4-6, 5,26 ERA) since June 6; On Wednesday the veteran had a rehab appearance with Triple-A Rochester, throwing three innings in white. Santiago did not allow hit and did 57 pitches, so it is expected that in this exit in Boston do between 75-80 pitches. On Monday, the Twins sent Dillon Gee to Rochester to make room for Santiago on the roster.

Full Game Coverage

Pomeranz was left without a decision on his way out to the Royals on Wednesday when he allowed two runs and six hits, gave a passport and struck out five in 6.1 innings.

Things to know about the game:

• Pomeranz has been pitching well recently, posting a 3.21 ERA with 46 strikeouts in 42 innings in his last eight starts. Pomeranz has twice faced the Twins, including one opening, allowing six runs (four clean) in 5.1 innings.

• Santiago had a good start this season with a 2.76 ERA in his first seven starts, but in his six subsequent appearances (five starts) he posted a 9.93 ERA before being put on the disabled list. The Twins, whose pitching has been tested in recent weeks, hope that now that Santiago is healthy he will return strong. The left-hander has had success against the Red Sox, posting a 3.05 ERA, with 47 strikeouts in 41.1 innings.

• Balls hit with the barrel and an ideal combination of starting speed and throwing angle are the most dangerous type of contact for a pitcher. Santiago has allowed a barrel in 11.6 percent of the balls put into play, the highest rate among 100 pitchers with at least 200 balls put into play this season.

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